Hi @Grimmers The Raspberry Pi 4 Model B is working well with the Analog Discovery 2 when connected to the USB 3 (blue) ports. It was running continuously for more than 24 hours. The connection to the device over the USB 2 (black) ports dropped after 6-12 hours. It looks like the problem was caused by the external USB hub. After connecting the AD2 directly to RPi4B USB 2.0 port it is working since 2 days.