Maybe a drawing would help. We started with no pull down resistors. We were getting some erratic data with our High Level transducers, so changed to the 2416 recommendation of 100K pull downs. Unfortunately, this configuration, with our Low Level transducer, put the two 100Ks in parallel with the bridge 5K strain gages. The transducer output at full pressure was about 600uV lower than without the pull downs (nominal 0-30mV). I'm not sure if this was due to just the parallel combination, or if the DAQ DGND isn't totally isolated from the P GND? When we tested with the Low Levels with the 5M pull downs, they didn't affect the Low Level output at full pressure, basically the same as no pull downs.
The concern is whether the 5Ms will adversely affect the High Level transducers? Note, the High Level transducers, on the Amp Board side, is a load cell with an instrumentation amplifier.
DAQ Hi_Lo Level.pdf