Thank you @Fausto. My BIOS on these systems were already set to Legacy, UEFI is OFF, and Secure Boot is disabled. This happens on multiple machines. We have standardized our lab on specific computer builds, so I don't have a lot of variation of hardware to test with. Although we do have a few different generations of hardware due to the vendor discontinuing our original motherboard hardware. Testing on some other more recently purchased machines, the issue does not appear to be present on the newer models. This is a little surprising since I would expect newer hardware to be less compatible with older DT boards, not better. The other possible contributing factors may be newer BIOS in the more recent machines, or newer Windows10 Updates applied in the newer machines. None of the older machines that exhibit the failure behavior have had any Windows Updates applied since they were put into service (over 5 years on some) since they are all behind a stand-alone test network VLAN with no internet access.
For reference, the systems I am having issues with are using Intel i3-4330 (LGA1150) based systems. The ones that are working normally are i3-6100/8100/9100 (LGA1151) based systems.
Is there any chance that the older systems are crashing because of missing Windows Updates? This seems unlikely since the DT QuickDataAcq app would've been written well before any recent updates, but maybe a more recent update could've fixed a legacy compatibility thing? Or is it more likely a hardware/BIOS layer thing?